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Angie Sin is an MBBS/PhD scientist with multidisciplinary research expertise. Her career goal is to develop a research career that interfaces basic science with clinical medicine, applying a background in medicine complemented by broad-based research skills. Over the years, her research focus has been clinically driven, emphasizing the unravelling of molecular mechanisms underlying disease progression, and the development of novel therapeutic strategies. She has worked on a wide range of cutting-edge research projects that elucidate signaling pathways to identify novel therapeutic targets for cardiac hypertrophy, targeted gene repair for rare genetic disorders using mouse and patient-derived induced pluripotent stem cells, a combination of CRISPR/Cas9 gene-editing and piggyBac technologies, fluorescence polarization-based high throughput assays for drug screening, and CRISPR-generated cell models for functional studies of collagen IV deficiency and drug validation using PROTACs in cancer cell lines.
University of Glasgow • Glasgow, GB
Conducting research focusing on molecular mechanisms underlying disease progression and developing novel therapeutic strategies.