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Dr. Le’s research focuses on investigating mesenchymal stem cells in adult oral tissues. Together with collaborators, he has isolated and characterized adult stem cells from gingival tissue—a discovery patented at USC. Studying stem cells further, Dr. Le proposed a new mechanism to aid wound healing; he suggested that stem cells modify the environment of wounds. This new concept positions stem cells as conductors, akin to musicians in an orchestra, in the process of wound repair. Dr. Le and his colleagues have secured NIH funding to explore research avenues aimed at regenerating missing craniofacial tissue. Threads of Dr. Le's research connect to the investigation of bisphosphonate-related osteonecrosis of the jaw (BRONJ), a condition involving degeneration of the mandible arising from the use of bisphosphonate-based drugs to treat cancer or prevent bone loss associated with osteoporosis. Research conducted in collaboration with mice has identified biomarkers that may indicate individuals at higher risk of developing osteonecrosis. They have also found that the infusion of mesenchymal stem cells can potentially cure this condition in mice, representing a promising breakthrough for patients suffering from this debilitating and painful disease.
Penn Dental Medicine • Philadelphia, PA
Leading research and academic initiatives in oral rehabilitation.
Ostrow School of Dentistry of USC • Los Angeles, CA
Taught and conducted advanced research in oral and maxillofacial surgery.
Ostrow School of Dentistry of USC • Los Angeles, CA
Engaged in surgical and bioengineering sciences research.
Wharton Doctoral programs cover fields like Finance, Marketing, Management, and Operations, Information and Decisions.