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Ann-Christin Brorsson is a Senior Associate Professor at Linköping University. Her research focuses on protein aggregation and amyloid pathogenicity, particularly related to human diseases such as dementia and diabetes. Her work investigates the molecular origins of amyloid diseases, including Alzheimer’s disease (AD) and Lysozyme amyloidosis (LA). AD is a neurodegenerative condition that progressively impairs mental functions in affected individuals. With approximately 5% of the population aged 65 and over affected, the prevalence of AD is expected to rise with increasing longevity, leading to significant economic costs and human suffering. LA, on the other hand, is characterized by systemic amyloidosis where protein aggregates can cause organ failure. Brorsson’s research explores the aggregation behavior of the Amyloid-beta (Abeta) peptide associated with AD and the lysozyme protein linked to LA using Drosophila melanogaster as a model. By employing a combination of in vitro biophysical studies and in vivo toxicity assessments, her aim is to identify toxic aggregates formed during the aggregation process and to develop novel therapeutic strategies to combat these devastating diseases.
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