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Anna Kashina is a Professor in the Department of Physiology at the University of Pennsylvania. She holds a PhD in Cell Biology from the Moscow Institute of Protein Research. Her research interests focus on protein modifications, mouse genetics, cancer, cytoskeleton development, cardiovascular development, and angiogenesis. Kashina investigates the physiological role of poorly characterized posttranslational modifications, particularly protein arginylation. Her work has revealed that knockout of the enzyme ATE1, responsible for arginylation, results in embryonic lethality in mice, highlighting its impact on heart development and blood vessel remodeling. With an interest in posttranslational modifications as a mechanism for regulating metabolism and disease, her research aims to identify protein targets of ATE1, study the molecular properties of ATE1 enzymes, and uncover the pathways leading to the global physiological effects of protein arginylation.
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