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Anne Goriely is a Professor of Human Genetics at the Radcliffe Department of Medicine, University of Oxford. Her research focuses on clinical genetics, particularly the role of genetic mosaicism in congenital diseases. Goriely's work has proven pivotal in understanding mutational rates and patterns that underlie genetic variation and disease. She has established that mutations can arise due to random miscopying events, particularly in the paternal germline, leading to what she describes as ‘selfish’ mutations that become enriched within the testis as men age. This phenomenon is linked to an increased risk of transmitting pathogenic alleles to offspring, contributing to the prevalence of rare Mendelian diseases associated with paternal age. Her research employs quantitative methods to address how oncogenic pathways and growth factor-receptor signaling influence spermatogonial cell renewal and their broader implications on neurogenesis and cancer predisposition. Goriely is actively involved in supervising DPhil students and projects related to these critical areas of genetic research.
Department of Politics and International Relations - Higher Level English requirement.