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Annett Müller is a researcher at Cambridge Cardiovascular, focusing on heart failure and regenerative medicine. Her work aims to develop innovative strategies for treating the underlying causes of heart failure to enhance patients' regenerative capacity. This involves the generation of cardiomyocytes, controlling inflammation, and inducing neovascularization processes. A significant aspect of her research is the development of modified platelets as site-specific delivery vehicles for pro-angiogenic proteins, supporting neovascularization in ischemic myocardium. She employs human induced pluripotent stem cells (iPSCs) to create megakaryocytes and functionally active platelets under GMP-compatible conditions, ensuring large-scale production that meets clinical standards. Annett's innovative approach includes creating ‘universal’ platelets that prevent immune reactions in recipients due to their deficient HLA class presentation, thereby enhancing tissue repair in conditions like myocardial infarction. Her contributions encapsulate both basic research and advanced therapeutic applications in the field of regenerative medicine.
Cambridge Cardiovascular • Cambridge
Conducting research focused on regenerative medicine and the development of innovative therapeutic strategies for heart failure.
Standard postgraduate requirements for Department of Politics and International Studies (POLIS) and related humanities departments.