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Anthony Kossiakoff is the Otho S.A. Sprague Distinguished Service Professor of Biochemistry and Molecular Biology at the University of Chicago. His scholarly interests focus on Antibody Engineering, Membrane Proteins, Phage Display Mutagenesis, Protein Engineering, and Structural Biology. Kossiakoff leads a group dedicated to understanding the molecular mechanisms underlying biological function. His research employs techniques such as X-ray crystallography and cryo-electron microscopy, along with site-directed mutagenesis and phage display. Notably, he has pioneered a technology termed 'chaperone-assisted' crystallography, facilitating structural analyses of protein systems that are otherwise challenging to study. His work also contributes to the development of synthetic antibodies, which hold the potential to replace traditional monoclonal antibodies in various applications such as live cell imaging and proteomics. With a Ph.D. in Physical Chemistry from the University of Delaware and a background that includes postdoctoral research at the California Institute of Technology, Kossiakoff has received numerous accolades, including the Christian Anfinsen Award from the Protein Society in 2019 and an Honorary Doctorate in Science in 2011.
Department of Biochemistry and Molecular Biology, University of Chicago • Chicago, IL
Led the Department, overseeing academic programs and faculty.
Institute of Biophysical Dynamics • Chicago, IL
Directed research and academic initiatives.
Department of Protein Engineering, Genentech, Inc. • San Francisco, CA
Managed protein engineering research and development.
Department of Philosophy