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Anthony Kossiakoff is the Otho S.A. Sprague Distinguished Service Professor at the University of Chicago, specializing in Biochemistry and Molecular Biophysics. His research primarily focuses on antibody engineering, membrane proteins, phage display mutagenesis, protein engineering, and structural biology. Kossiakoff's group employs a combination of techniques including X-ray crystallography, cryo-electron microscopy, site-directed mutagenesis, phage display, and biophysical analysis to study the molecular mechanisms governing biological functions. The group pioneered the chaperone-assisted crystallography technique, which aids in the structural analysis of protein systems that are difficult to assess using traditional methods. His work has been influential in the development of synthetic antibodies, which offer potential alternatives to conventional monoclonal antibodies, especially in applications such as live cell imaging and proteomics. Kossiakoff has authored multiple publications in renowned scientific journals and has received several prestigious awards throughout his career.
Department of Biochemistry and Molecular Biology, University of Chicago • Chicago, IL
Led the Department of Biochemistry and Molecular Biology.
Institute Biophysical Dynamics • Chicago, IL
Directed the Institute focused on biophysical research.
Department of Protein Engineering, Genentech, Inc. • California
Managed the department responsible for protein engineering research.
Department of Philosophy