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Antoni Wrobel seeks to understand how enveloped viruses evolve, using knowledge to manage responses to future pandemics. His research focuses on the molecular mechanisms underlying viral evolution and host interactions, specifically with deadly human pathogens like influenza and SARS viruses. He investigates questions such as the sufficiency of viral components to fulfill functions necessary for infection, the multifunctionality of viral proteins, and the ways viruses engage host machineries. The recent COVID-19 pandemic highlighted the importance of understanding how new viruses evolve and transmit between hosts. Wrobel utilizes biochemical, biophysical, and structural methodologies, predominantly cryo-electron microscopy (cryoEM), to reveal the mechanisms by which SARS-CoV-2 infects humans and adapts to optimize its infectivity. His lab continues to study coronaviruses and influenza viruses to decipher how viral proteins attain the versatility needed to infect various hosts. His long-term goal is to leverage structural and mechanistic insights to guide the design of new antivirals and vaccines for zoonotic viruses, directly impacting public health and pandemic preparedness.
Department of Politics and International Relations - Higher Level English requirement.