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Arnim Pause is a Professor in the Department of Biochemistry at McGill University, dedicated to advancing our understanding of cancer biology. His research emphasizes the functional characterization of the FLCN-AMPK pathway in relation to Birt-Hogg-Dubé syndrome, a hereditary condition that increases the risk of renal carcinoma among affected individuals. His work reveals that mutations in the FLCN gene disrupt its regulatory role on AMPK, leading to significant metabolic alterations in tumor cells. Dr. Pause’s investigations into the role of the ESCRT component HD-PTP/PTPN23 further explore the mechanisms of tumor suppression. His laboratory utilizes both mammalian and C. elegans models to study cancer phenotypes and the molecular dynamics of receptor signaling. Through his thorough investigation, Dr. Pause aims to unveil novel therapeutic targets and improve cancer treatment outcomes.
Department: Department of Medicine. Program: Experimental Medicine.