Dr. Arthur Kaser

Biography

Arthur Kaser is a Professor of Gastroenterology at the University of Cambridge, specializing in the field of academic gastroenterology. His research provides fundamental insights into the mechanisms underlying inflammatory bowel diseases such as Crohn’s disease and ulcerative colitis. Professor Kaser's work includes the creation and use of genetically engineered mice to study dysregulation of intrinsic processes in enterocytes, which contribute to the development of these diseases. He leads the Gastrointestinal Diseases theme at the NIHR Cambridge Biomedical Research Centre, in partnership with Cambridge University Hospitals, aiming to translate novel insights into therapeutic opportunities for patients. His laboratory investigates the biology of these conditions, focusing on the complex interactions between genes and environmental factors. Techniques employed in his research include advanced genetic models and sophisticated liquid chromatography mass spectrometry to uncover major biological mechanisms influenced by genetic risk factors. Among his significant findings is the discovery of a fundamental purine enzyme that balances electron transfer in mitochondria, thereby controlling immunometabolism in macrophages. Professor Kaser is also involved in running clinical trials at Addenbrooke’s Hospital, which support proof-of-concept studies and early phase clinical development programs.

Research Interests

Experience