Dr. Arthur Salomon

Biography

Arthur R. Salomon is a Professor in the Department of Molecular Biology, Cell Biology, and Biochemistry at Brown University, specializing in the elucidation of signaling networks relevant to human disease. His research primarily focuses on exploring perturbations in phosphorylation patterns induced by pharmacological agents. Utilizing quantitative phosphoproteomic analysis mass spectrometry techniques, his laboratory is capable of efficiently profiling tens of thousands of phosphorylation sites in cells and tissues over time. Salomon's work involves mapping complex signaling networks in T cells to enhance the understanding of T cell signaling pathways at a molecular level. A comprehensive understanding of dynamic cellular processes is attained through the simultaneous detection of changes in the levels of phosphorylation across numerous proteins over time and space within the cell. Salomon’s methodological advancements in mass spectrometry provide significant utility in addressing complex problems within the fields of pharmacology and cellular biology, particularly through the identification of novel signaling pathway members that can serve as targets for drug development. His successful projects include studies related to the BCR/ABL kinase inhibitor STI571 and the HER2 receptor protein tyrosine kinase inhibitor Herceptin, which illustrate the viability of targeting specific pathway members for disease treatment. He holds a PhD from Brown University and has received multiple awards, including the Beckman Young Investigator Award and funding from NIH grants.

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