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Dr. Ashraf Zaman is a conjoint lecturer of Medicine and a research fellow at the Garvan Institute of Medical Research. He completed his PhD at UNSW, where he established Australian low-grade brain tumour models. Dr. Zaman was instrumental in a preclinical study that led to the repurposing of an asthma drug for treating terminally ill brain cancer patients, which is currently used in clinical trials at Dana Farber Cancer Institute, Harvard Medical School. His current research focuses on understanding the cellular heterogeneity of adult and pediatric high-grade gliomas by leveraging single-cell spatial sequencing technologies. In collaboration with Professor Joseph Powell's lab at the Garvan Institute, he has played a crucial role in developing a comprehensive brain cancer cell atlas that captures data from 1.2 million cells across 200 brain tumour samples. Utilizing this data, he leads the development of patient-derived brain cancer organoids for high-throughput drug screening. Dr. Zaman is actively involved in developing national and international alliances for brain cancer research, aiming to enhance treatment options and improve the prognosis for brain tumour patients.
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