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Audrey Claing is a Professor at the Department of Pharmacology and Physiology at the Université de Montréal. Her research program focuses on the molecular mechanisms regulating cellular responses to stimuli, particularly through the largest family of transmembrane receptors, the G protein-coupled receptors (GPCRs). With over 40% of pharmaceuticals targeting these proteins, her work has significantly contributed to understanding the signaling pathways activated by various stimuli, including light and hormones. Her group's research emphasizes the role of ADP-ribosylation factors (ARFs) as molecular switches that control actin cytoskeleton remodeling and plasma membrane lipid transformation. These pathways are essential for vesicle formation and cellular signaling, with a notable application in identifying new therapeutic targets for diseases such as breast cancer. Claing’s lab employs diverse cellular models, including breast cancer endothelial cells, to explore the implications of ARF proteins in intracellular signaling and their potential as targets for innovative cancer therapies.
Department of Pharmacology and Physiology - Research intensive with options in Neuropharmacology and Pharmacogenomics.