Dr. Augusto Andrade

Biography

Augusto Andrade is a cancer biologist specializing in pediatric neuro-oncology. He obtained his PhD from the University of São Paulo, where he worked under Professor Luiz Gonzaga Tone. He completed his research training in the laboratory of Dr. Nada Jabado at McGill University, focusing on the tumor microenvironment of pediatric gliomas, particularly the role of immune cells. His work has significantly contributed to understanding the interplay between chromatin state and immune cells in shaping tumor progression and therapeutic response. Dr. Andrade has established a research laboratory at the University of Calgary in the Department of Biochemistry and Molecular Biology, Cumming School of Medicine. His research focuses on understanding the brain microenvironment in cancer within neurodevelopmental contexts, with particular emphasis on gliomas and neurodegeneration. He integrates cutting-edge technologies, including single-cell spatial transcriptomics and imaging mass cytometry, alongside in vivo experimental models to explore how epigenetics shapes disease progression. A key area of his investigation examines the interplay between immune infiltration and chromatin state in brain tumors. Given the challenges of treating aggressive cancers, his aim is to uncover how epigenetic dysregulation influences immune cell behavior, contributing to tumor formation and therapy resistance. By utilizing human tumor samples, transgenic mouse models, and patient-derived glioma cells, he employs transcriptomic and epigenomic approaches to deeply characterize immune populations and their epigenetic landscapes, ultimately paving the way for novel therapeutic strategies.

Research Interests

Experience

Awards