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Azim Surani is a distinguished researcher focused on mammalian germ cells and pluripotency. His work delves into the mechanisms that regulate cell fate decisions during early development, specifically investigating the molecular basis of primordial germ cell specification through a tripartite genetic network involving Prdm1, Prdm14, and Tcfap2c. His studies employ in vivo approaches and cell-based systems to generate PGC-like states using pluripotent stem cells. Surani examines the epigenetic programming of PGCs, including extensive histone modifications and changes in nuclear organization. His notable contributions include uncovering the roles of Tet1 and Tet2 in achieving an epigenetic ground state characterized by global DNA demethylation. Additionally, he explores the relationship between germ cells and pluripotent stem cells, aiming to understand the genetic factors that induce ground state pluripotency and promote transitions across epigenetic barriers during reprogramming. Surani's investigations have significantly advanced our understanding of germ cell biology and the implications for cellular rejuvenation and regenerative medicine.
Germline Epigenomics Research • Cambridge
Leading an innovative research program focusing on the role of epigenetics in germ cell development and pluripotency.
Standard postgraduate requirements for Department of Politics and International Studies (POLIS) and related humanities departments.