Dr. Barani Rajendran

Biography

Barani Kumar Rajendran is a well-trained translational cancer bioinformatics scientist with expertise in integrative genomics, epigenetics, and immuno-oncology. His research primarily focuses on breast cancer, lung cancer (Non-Small Cell and Small Cell), and colorectal cancer, emphasizing tumor evolution, immune evasion, and therapeutic resistance. He applies multi-omics approaches, including whole exome/genome/transcriptome/epigenome sequencing, copy number variation, spatial transcriptomics, and single-cell technologies like single-cell RNA sequencing and scATAC-seq to dissect tumor-immune interactions and treatment response. Dr. Rajendran has extensive experience leading multiple clinical trial projects, integrating molecular and clinical data to identify biomarkers of response and resistance. He develops reproducible computational frameworks for analyses such as somatic variant identification, copy number aneuploidy, epigenomic profiling, chromatin analysis, neoantigen prediction, and antigen processing and presentation pathway analysis, contributing to collaborative, multidisciplinary research that advances precision oncology and targeted therapies, including immunotherapy and DNA damage-based treatments.

Research Interests