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Barry Grant's research focuses on the development and application of state-of-the-art computational theoretical techniques to investigate the structure and dynamics of biomedically important proteins. His work interfaces molecular biology, biophysics, and bioinformatics, providing unique insights gained from research that is tightly coupled with a wide range of biochemical and biophysical experiments. Through this approach, he has developed a new class of allosteric Ras and Rho molecular switch inhibitors, reported on rationally designed faster velocity kinesin motors, and demonstrated how the time kinesin processivity can be modulated by rational mutations in the motor domain. Additionally, he discovered key atomistic detriments to allosteric activation of G proteins and developed the Bio3D software package, which is used by thousands of researchers around the world. His specific areas of expertise include bioinformatics, biomolecular simulation, and drug discovery and design, focusing on virtual screening, structure-based drug design, and cheminformatics molecular modeling to support drug discovery efforts.
University of Michigan • Ann Arbor, MI
Administered by the Scripps Institution of Oceanography. Curricular groups include Climate-Ocean-Atmosphere (COAP), Geosciences (GEO), and Ocean Biosciences (OBP).