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Ben E. Black, Ph.D. is the Eldridge Reeves Johnson Foundation Professor in the Biochemistry Biophysics Department at the Perelman School of Medicine, University of Pennsylvania. His research focuses on understanding the centromere, a crucial chromosomal element that directs the accurate segregation of chromosomes during cell division processes such as mitosis and meiosis. His lab employs a range of biophysical, biochemical, genetic, and epigenomic approaches to dissect the composition and physical properties of protein-DNA complexes within the centromere. Recently, his work has also advanced to explore the PARP-1 enzyme, a key player in DNA damage signaling and a significant clinical target for small molecule inhibition. He has discovered various allosteric networks activating PARP-1 upon DNA break binding and is involved in developing designer PARP inhibitors with tuned effects for potential cancer therapies and neuroinflammatory diseases. Black has contributed extensively to the field through various publications and collaborations, looking to advance technologies in building synthetic chromosomes for research and medical applications.
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