Professor Dr. Ben Cosgrove

Biography

Ben Cosgrove directs the Laboratory of Regenerative Systems Biology at the Meinig School of Biomedical Engineering, Cornell University. His research group develops and implements systems bioengineering approaches to study the transcriptional signaling network dysregulations underlying the decline in muscle stem cell function and tissue regeneration in aging and disease. Cosgrove Laboratory consists of biomedical engineers and stem cell biologists who are broadly interested in understanding muscle stem cells and using integrative actions of regulatory circuitry to interpret the balance of diverse streams of microenvironmental 'information'. Key research questions include developing single-cell analysis modeling approaches to dissect muscle stem cell fate outcomes dictated by diverse niche microenvironmental signals, elucidating the logic of autocrine and paracrine signaling networks influencing muscle stem cell fate decisions in homeostatic and regenerating muscle, and engineering biomimetic microenvironments to evaluate stem cell-niche interactions for cell manufacturing applications. These approaches aim to enhance the rational design of quantitatively predictive stem cell-targeted regenerative medicine therapies for treating tissue aging and degeneration.

Research Interests

Awards