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Professor Benjamin Blencowe specializes in Molecular Genetics at the University of Toronto. His research focuses on understanding the mechanisms underlying gene expression regulation and its disruptions in human diseases. He has greatly contributed to the fields of bioinformatics and computational biology, implementing a variety of molecular and biochemical methods alongside generating animal models. Notably, he has discovered critical roles of alternative splicing 'switches' in the regulation of transcriptional programs essential for neural and embryonic stem cell fate. His highly collaborative work has revealed a regulatory network comprising conserved neuronal microexons, linking their disruption to autism spectrum disorders. Furthermore, Blencowe's pioneering technologies in genome-wide transcriptome profiling and CRISPR-based methods have refined our understanding of RNA regulatory networks, providing insights that could lead to innovative therapeutic strategies for various human disorders.
Department of Sociology