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Professor Rusak's research deals with the mechanisms regulating circadian rhythms and sleep, focusing on the application of knowledge about these mechanisms to issues in human health. His current projects include studies on the effects of sleep loss on mood, cognition, memory, daily hormone rhythms, and pain sensitivity. Over the years, he has published key papers on the suprachiasmatic stimulation and its effects on circadian rhythms, as well as the role of neurotransmitters in the mammalian circadian system. He has also investigated how light pulses can shift rhythms and induce gene expression in the suprachiasmatic nucleus, and the impacts of sleep restriction on brain chemistry and mood in women with unipolar depression.