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Bill Roesler obtained his PhD from the Department of Biochemistry at the University of Saskatchewan. He completed a postdoctoral fellowship in Cleveland, Ohio, before joining the faculty in 1990. In 2011, he became the head of his department. Roesler's teaching and research focus on transcription factor regulation. He enjoys a range of outdoor activities. His lab investigates the structure and function of nuclear speckles, which are interchromatin granule clusters found in the nucleus of mammalian cells. These specialized compartments are associated with gene expression and contain splicing factors and transcription factors. His current research centers around TCERG1, a protein enriched in nuclear speckles, which plays an inhibitory role in transcriptional regulation. Roesler is working to characterize the domains of TCERG1 and its interactions with transcription factors, specifically C/EBPa, to understand the mechanisms of transcriptional regulation.
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