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Bill Willmore is a Professor in the Institute of Biochemistry at Carleton University. His research primarily focuses on the alterations in protein structure and function under hypoxic conditions, which are often faced by humans living at high altitudes or suffering from clinical conditions such as sleep apnea and heart disease. A significant aspect of his work is investigating how systemic and localized hypoxia affects metabolic pathways and induces angiogenesis. His lab uses mammalian cell lines to examine changes in protein expression and stability in varying oxygen levels. Willmore’s recent projects also delve into the role of oxidative modifications by reactive oxygen species on proteins, employing techniques such as gene cloning, protein expression in mammalian cell lines, and structure/function studies involving site-directed mutagenesis.
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