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Blanche Capel is a James B. Duke Distinguished Professor in the Department of Cell Biology at Duke University. Her research focuses on male sex determination, specifically the initiation of testis development from the bipotential gonad primordium, which is regulated by the Sry gene located on the Y chromosome. Throughout her career, she has developed an interest in germ cells, which are essential for the formation of eggs and sperm. Capel's work has led to a deeper understanding of the communication between Sertoli cells and germ cells during fetal development and beyond. Using innovative techniques, including a proprietary AAV system for CRISPR tagging, she has explored how Sertoli cells influence germ cell development at various stages. This research has implications for understanding fertility and sex determination mechanisms in mammals.
Department of Biomedical Engineering (MS program)