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Boris Striepen is a professor in the Department of Microbiology at the University of Pennsylvania's Perelman School of Medicine. His research expertise revolves around cell and molecular biology, particularly how parasites interact with mammalian hosts. In recent years, his work has focused on the apicomplexan Cryptosporidium, a distant cousin of the parasite that causes malaria. Cryptosporidium is a significant pathogen known for its role in waterborne disease outbreaks and is recognized as an opportunistic infection in individuals with AIDS. It is linked to a high number of diarrheal disease-related deaths, especially among infants. Striepen's lab emphasizes genetic manipulation of the parasite and developing mouse infection models to study its biology and pathology. Research areas include understanding how the parasite invades intestinal epithelial cells, the sexual phase of its lifecycle, and the interaction of host immune responses with Cryptosporidium infection. Students and trainees in his lab utilize a variety of modern approaches such as single-cell sequencing, super-resolution live-cell microscopy, and cryo-electron tomography.
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