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F. Bradley Johnson, MD, PhD, is a Professor in the Department of Pathology and Laboratory Medicine at the Perelman School of Medicine, University of Pennsylvania. His expertise lies in the field of molecular biology with a primary focus on aging and its implications in various diseases including cancer, pulmonary fibrosis, and neurodegeneration. His research investigates telomere biology and its links to human aging. Telomeres, the protective caps at the ends of chromosomes, are critical for maintaining genomic stability and are subject to damage due to various environmental factors. As individuals age, telomere length shortens, which correlates with increased susceptibility to age-related diseases and cancer. In his laboratory, he employs human induced pluripotent stem (iPS) cells to study telomere-driven diseases, including the impact of telomere dysfunction on specific cell types involved in organ function. His ongoing projects aim to model the biological consequences of telomere shortening in various tissues and their relationship to disease pathogenesis.
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