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Bradley L. Pentelute is a Professor in the Department of Chemistry at the Massachusetts Institute of Technology. His research focuses on developing new protein modification chemistries that adapt nature's molecular machines for efficient macromolecule delivery to cells. The Pentelute Lab is particularly interested in discovering peptide binders for proteins and inventing flow technologies for rapid biopolymer production. By overcoming the challenges posed by proteins containing 20 amino acids with reactive functional groups, his lab has developed efficient, selective chemistries for modifying amino acids, and has produced a toolkit for creating potent bioconjugate molecules, including peptide macrocycles. The lab's advancements in automated flow technology allow for the rapid manufacture of proteins and the development of personalized therapies and cancer vaccines. They engineer nontoxic forms of anthrax toxin for targeted delivery of cargo molecules into cells. By leveraging machine learning, Pentelute's team can predict and design best-in-class peptide variants, leading to breakthroughs in the discovery of affinity reagents for native proteins. The lab utilizes high-throughput identification techniques, contributing to the advancement of therapeutic approaches in chemical biology and medicine.