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Brenton D. Hoffman is an Associate Professor in the Department of Biomedical Engineering at Duke University. His research program focuses on the interdisciplinary understanding of mechanotransduction across multiple scales, aiming to advance basic knowledge and develop new treatments for mechanosensitive diseases. He integrates methodologies from protein engineering, molecular biology, soft matter physics, and biomaterials engineering to explore the dynamic interactions of living cells with their environment. A significant aspect of his work involves the development of biosensors that report mechanical tension within specific proteins, allowing for real-time measurement of subcellular structures at the molecular level. This innovative technology positions his research at the intersection of various fields including molecular biology and biophysics, fostering a deeper understanding of how mechanical and chemical cues influence cellular responses. His commitment to education is reflected in his teaching awards and the courses he offers, including graduate studies in cell mechanics and biomedical engineering.
Department of Biomedical Engineering (MS program)