Dr. Brian Bigger

Biography

Brian Bigger is an Honorary Professor at the University of Manchester, specializing in Cell Gene Therapy. He completed his Bachelor's degree in Applied Biology at the University of Bath and conducted his PhD at the Imperial College, London, where he worked on the development of gene delivery vehicles for mitochondrial gene therapy. After completing his PhD in 2000, he joined the Wellcome Trust collaborative project at Imperial College, focusing on gene delivery to stem cells for liver diseases. He became a Senior Research Scientist at Oxford University, involved in stem cell homing mechanisms. In 2006, Bigger established the Stem Cell & Neurotherapies laboratory at the University of Manchester and the Royal Manchester Children's Hospital. His research primarily addresses the challenges of neurodegenerative metabolic diseases in children, particularly lysosomal storage disorders such as Mucopolysaccharidosis (MPS). The laboratory employs a multidisciplinary approach to investigate gene therapies for neurological diseases and includes programs focused on biomarker development and clinical applications of stem cell therapies. Bigger's work is essential in advancing treatment methods for complex conditions and has seen collaboration with several key figures in neuroscience and regenerative medicine.

Research Interests

Experience