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Brian C. Capell, M.D., Ph.D., is an Assistant Professor in the Department of Dermatology at the Perelman School of Medicine, University of Pennsylvania. His research focuses on the intersection of epigenetics, cancer, immunity, and metabolism. Dr. Capell's laboratory, the Capell Lab, aims to understand how the epigenome influences cellular homeostasis and contributes to diseases such as cancer, inflammation, and aging in epithelial tissues. His clinical expertise lies in squamous cell carcinoma and associated skin conditions. Dr. Capell is particularly interested in how epigenetic mechanisms regulate gene expression and cell fate, with implications for understanding and treating various diseases. The lab employs innovative in vivo models alongside human patient samples to uncover therapeutic vulnerabilities in cancer treatment. Dr. Capell's work also investigates significant questions regarding the interplay between epithelial tissues and the immune system, especially in light of environmental insults like UV radiation. Moreover, the lab studies the impact of diet and lipid metabolism on cancer signaling and therapies that could enhance disease management.
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