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Dr. Brian Capell is an Assistant Professor in the Department of Dermatology at the University of Pennsylvania. He holds an MD and a PhD in Cellular Molecular Biology from New York University, with the latter earned in 2008. His clinical expertise includes squamous cell carcinoma, actinic keratoses, basal cell carcinoma, and melanoma. His research focuses on epigenetics and its intersections with cancer, immunity, and metabolism. The Capell Lab investigates how the epigenome impacts cellular homeostasis and contributes to cancer, particularly in epithelial tissues like skin. The lab employs both in vivo models and human patient samples combined with cutting-edge epigenetic approaches to identify therapeutic vulnerabilities and novel treatment targets. A significant aspect of his research explores the interplay between the epigenome and the immune response, particularly in the context of skin cancer and other epithelial diseases. Dr. Capell has also made contributions to understanding how diet and lipid metabolism influence oncogenic signaling and antitumor immunity. His work on sex chromosome complements aims to elucidate the mechanisms behind the observed sex differences in various diseases, including skin cancer. He is affiliated with several medical centers and institutes, including the Pennsylvania Hospital and the Abramson Cancer Center.
Hospital University of Pennsylvania, Department of Dermatology • Philadelphia, PA
Clinical practice and training in dermatology, specializing in skin cancer.
Data Sciences Informatics Core, Penn Skin Biology Diseases Resource-based Center • Philadelphia, PA
Overseeing the data sciences informatics core related to skin diseases.
Epigenetics Institute, University of Pennsylvania • Philadelphia, PA
Conducted research focusing on the intersection of epigenetics and skin biology.
Wharton Doctoral programs cover fields like Finance, Marketing, Management, and Operations, Information and Decisions.