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Brian Capell, M.D., Ph.D., is an Assistant Professor in the Department of Dermatology at the Perelman School of Medicine, University of Pennsylvania. His research focuses on epigenetic mechanisms in epithelial biology, cancer, and immunity, particularly the role of the epigenome in maintaining cellular homeostasis and its contribution to cancer and inflammatory diseases. Capell's lab employs innovative in vivo models and human patient samples to uncover fundamental questions regarding how epigenetic alterations affect metabolism, immunity, and skin cancer. His clinical expertise includes treating various skin cancers, emphasizing understanding the intersection of epigenetics and epithelial biology. He has identified key epigenetic regulators involved in lipid metabolism and ferroptosis, exploring therapeutic opportunities to treat conditions influenced by diet and metabolism. Additionally, Capell is investigating the sex chromosome complement's role in sex bias concerning disease incidence and outcomes, particularly in skin cancer and autoimmune diseases. His work contributes to a deeper understanding of the cellular processes driving these diseases and aims to enhance targeted therapies for patients.
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