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Brian D. Gregory is a Professor in the Department of Biology at the University of Pennsylvania. He specializes in computational biology and plant biology, focusing on the mechanisms regulating RNA modifications and post-transcriptional regulation. His research utilizes genomic, bioinformatic, and systems biology approaches alongside molecular genetic and biochemical techniques to identify and characterize additional components required for the metabolism and function of RNA chemical modifications such as N6-methyladenosine and NAD+ caps. The lab employs a genetic approach using the model organism Arabidopsis thaliana to identify new factors involved in writing, erasing, and reading chemical additions to RNA molecules, uncovering the functionalities of covalent modifications in post-transcriptional regulation. Furthermore, the lab studies highly conserved pathways by investigating RNA modifications in animal models. The findings will contribute to the understanding of RNA modification functions and the manipulation of gene expression in eukaryotic systems. Utilizing high-throughput sequencing, the lab pioneers developments to simultaneously study RNA secondary structure and RNA-protein interactions on a global scale. The combination of classical nuclease-based structure mapping techniques and high-throughput sequencing technology allows for an in-depth interrogation of protein binding profiles and the pairing status of nucleotides in RNA molecules across eukaryotic organisms.
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