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Brian Kobilka is a Professor in the Department of Molecular Cellular Physiology at Stanford University. His research focuses on adrenergic receptor biology, which play a critical role in the regulation of cardiovascular function. Kobilka's laboratory investigates the dimensional structure of adrenergic receptors and the conformational changes that facilitate signal transduction, employing experimental approaches such as mutagenesis and biochemical studies. Additionally, he studies the intracellular trafficking of adrenergic receptors, examining how changes in receptor structure, such as phosphorylation, affect their localization and functionality. Kobilka’s research also includes exploring the physiological relevance of adrenergic receptor subtype diversity through targeted gene modification in mice. His work is fundamental in understanding how different subtypes influence neural and cardiovascular physiology.
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