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Brian McCabe is a researcher at the École Polytechnique Fédérale de Lausanne (EPFL), specializing in Motor Neuroscience with a focus on understanding the molecular and cellular underpinnings of the neuronal circuit networks that comprise the motor system. His work aims to elucidate mechanisms that lead to neurodegenerative motor disorders, such as Spinal Muscular Atrophy (SMA) and Amyotrophic Lateral Sclerosis (ALS). Utilizing advanced neurogenetic techniques enabled by molecular genome engineering, his research employs Drosophila as a model organism due to its genetic conservation with humans. This research foundation is further augmented by studies in rodent models and human samples to provide insights into aging and neurodegeneration. In addition to research, McCabe is involved in teaching interdisciplinary courses that encourage creativity and critical thinking in life sciences and engineering, focusing on the engineering of genetic circuits and function of genomes.
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