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Brock Grill’s overarching interest is understanding the signaling influences on the development and function of the nervous system. His team’s major research directions include using in vivo proteomics to decipher the activity of ubiquitin ligases and how intracellular signaling hubs affect axon termination and synapse maintenance in neuron function. Another focus involves employing engineered forward genetic approaches to interrogate how u-opioid receptor sensitivity and tolerance are regulated. Ultimately, Grill’s lab aims to identify new molecular targets for treating neurodevelopmental disorders, neurodegenerative diseases, and issues related to opioid addiction and withdrawal.
Center for Integrative Brain Research • Seattle Children's Research Institute
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