Dr. Bruce Clurman

Biography

Bruce Clurman, MD, PhD, is a Professor in Translational Science at Fred Hutch and an Executive Vice President, Chief Scientific Officer, and Deputy Director at the institute. His research focuses on the cell cycle and molecular pathways that drive cellular proliferation. Dr. Clurman's work aims to understand the protein degradation mechanisms of the ubiquitin–proteasome system, specifically its role in regulating the cell cycle in both normal and cancerous cells. One of his significant research fronts includes developing treatment strategies that exploit mutations in cell growth-accelerating genes such as CDKs, pushing cancer cells beyond their capacity to cope with DNA damage while sparing healthy cells. He is investigating mutations in the Fbw7 gene, which is crucial for regulating tumor-driving proteins' destruction, with the goal of designing drugs that can restore function to mutant Fbw7 in cancers and curtail tumor growth. Dr. Clurman is affiliated with various integrated research centers at Fred Hutch and holds adjunct professor positions at the University of Washington in the Departments of Medicine and Pathology.

Research Interests

Experience