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Bruce D. Freedman, V.M.D., Ph.D. is a faculty member at the Perelman School of Medicine at the University of Pennsylvania. His research interests are centered around signal transduction mechanisms in immune cells, focusing on the physiological processes that regulate the development and function of lymphocytes and macrophages. He specifically studies the pathways that govern calcium signaling in T and B cells, exploring how different antigenic and regulatory stimuli contribute to functionally specific calcium signals that translate into biological responses during lymphocyte development and differentiation. His lab also investigates the viral and cellular determinants of viral tropism and pathogenesis, with an emphasis on the signal transduction pathways activated in human macrophages and T cells, particularly in the context of HIV-1 envelope protein (gp120) interactions with CD4 and chemokine receptors. Freedman's ultimate goal is to understand the functional consequences of these signaling mechanisms during viral entry and post-entry phases of viral replication, as well as their effects on target cell functions beyond the infection itself.
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