Dr. Bruce Levy

Biography

Bruce David Levy is the Parker B. Francis Professor of Medicine at Harvard University. His research focuses on the endogenous mechanisms that resolve lung inflammation and injury. The mission of the Levy Lab is to identify natural small molecule regulators that influence the severity and duration of innate and adaptive immune responses in the lung, particularly in relation to human diseases such as asthma. He has a particular interest in the molecular signaling circuits of autacoids that promote resolution, including lipoxins, protectins, resolvins, and other mediators derived from arachidonic acid and omega-3 fatty acids. Additionally, Dr. Levy has laid the groundwork for polyisoprenyl phosphate remodeling, serving as a new counter-regulatory signal transduction pathway for leukocytes and lung parenchymal cells. His research actively translates basic observations of the genesis of human illness into a deeper molecular understanding of the pathobiology of inflammatory lung disease, which is aimed at developing new therapeutic strategies for refractory lung diseases, including acute lung injury/ARDS and severe asthma.

Research Interests