Dr. Bruce Reed

Biography

Bruce Reed is an expert in developmental cell biology who utilizes the model organism Drosophila to investigate fundamental questions in cell developmental biology. His research focuses on the regulation of programmed cell death (PCD) in the extra-embryonic tissue known as amnioserosa, which undergoes PCD during dorsal closure. This provides an excellent system for studying PCD through live imaging. Reed's work examines several processes associated with PCD, including caspase activation, autophagy, contact dependent inhibition of PCD, and EGFR/Ras/MAPK dependent survival signaling. He is particularly interested in the interplay between caspase activation and autophagy during programmed cell death in the amnioserosa. Additionally, his lab studies the gene hindsight (hnt), a Drosophila homolog of human RREB1, which plays a crucial role in various developmental contexts. Hnt loss-of-function mutants exhibit premature death of the amnioserosa, hindering essential morphogenetic processes. Reed's recent projects explore the role of hnt in adult intestinal stem cells and their differentiation. He has been recognized with multiple awards, including the Foundation Advanced Cancer Studies Life Sciences Research Foundation Post-Doctoral Fellowship and the University of Guelph Beckman Prize in Molecular Biology & Genetics.

Research Interests

Experience

Awards