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Bruce Uhal is a Professor at Michigan State University, where he conducts significant research in the Department of Physiology, focusing on Idiopathic Pulmonary Fibrosis (IPF) and related interstitial lung diseases. His laboratory's goal is to understand the mechanisms controlling apoptosis in lung epithelial cells, which is critical as apoptosis is recognized as a hallmark feature in the histopathology of IPF lungs. Uhal's work has established that lung epithelial cells from IPF patients exhibit an unusually high rate of apoptosis, challenging traditional views that categorized this as 'hyperplastic.' His research employs various experimental models, including mouse and rat models of lung fibrosis, pathologic specimens from patients with IPF, and cell culture models using primary cell isolates from lung epithelial and mesenchymal cells. Uhal's current investigations also explore the enzyme ACE-2 and its role in regulating the fibrotic response through the degradation of angiotensin II. His groundbreaking studies have led to the identification of potential molecular targets for new therapeutic interventions in the treatment of IPF.
Department of Psychology