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The LevBuck Laboratory at Weill Cornell Medicine focuses on the messenger molecule cAMP, which modulates cell growth and differentiation in both bacteria and higher eukaryotes. The lab studies adenylyl cyclases, which produce cAMP, and possess distinct classes such as hormone-responsive transmembrane adenylyl cyclases and bicarbonate-regulated Soluble Adenylyl Cyclase. By purifying and cloning these various forms, the lab investigates eukaryotic cells and how cAMP functions as a messenger, playing numerous roles at the single-cell level. They have achieved compartmentalization of signaling within microdomains that are regulated independently and distributed throughout the cell. The location of sAC in multiple intracellular sites highlights its role in cAMP signaling. Their research aims to understand the regulation of bicarbonate-anions and the implications of sAC as they relate to carbon dioxide and pH signaling in cells, tapping into fundamental questions of science and biology.
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