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Bum-Rak Choi is an Associate Professor in the field of Medicine at Brown University, focusing on research into cardiac arrhythmias. His work aims to understand the mechanisms behind the initiation and maintenance of these conditions, particularly through studying mutations in ion channels and abnormal calcium handling. Dr. Choi has developed innovative dual imaging systems that enable simultaneous recordings of membrane potential and calcium levels in intact hearts using advanced fluorescence probes and high-speed cameras. His research dives into the pathological conditions like ischemia-reperfusion that induce arrhythmias, as well as atrial and ventricular fibrillation, and heart failure. Additionally, he explores neuronal mechanisms that trigger ventricular arrhythmias in transgenic animal models of long QT syndrome. His projects investigate action potentials and calcium transients in relation to the structure of the cardiac conduction system, particularly the role of the AV node and Purkinje fiber network in arrhythmogenesis.
Department: Department of Economics