Dr. C Mcmanus

Biography

C. Joel McManus is an Associate Professor in the Department of Biological Sciences at Carnegie Mellon University. His educational background includes a Ph.D. from the University of Wisconsin, Madison, and a postdoctoral appointment at the University of Connecticut Health Center. His research primarily focuses on understanding how variations in gene expression contribute to phenotypic diversity and disease, particularly through mechanisms regulating mRNA translation in fungal species. McManus's lab utilizes innovative high-throughput assay systems to identify RNA cis-regulatory elements that affect translation, aiming to build computational models that predict mRNA function based on upstream open reading frames (uORFs) and other genetic factors. His work has significant implications for understanding translational control in various biological contexts, including pathogenic responses to host immunity by fungi like Candida albicans. McManus has published extensively in this field, contributing to high-impact journals and advancing knowledge in the area of gene expression regulation and RNA biology.

Research Interests