Dr. Caleigh Mandel Brehm

Biography

Caleigh Mandel-Brehm's research seeks to advance the understanding of the molecular and cellular underpinnings of neuro-immune interactions associated with human autoimmune pathology. Her PhD training at Harvard Medical School, under Dr. Michael Greenberg, focused on molecular neuroscience and behavior. She broadened her experience during her postdoctoral work with Dr. Joseph DeRisi at UCSF, where she built molecular tools to study autoimmune responses in humans with idiopathic neurological disorders. Her prior training places her lab in a unique position to tackle outstanding questions regarding autoimmune pathologies in the central nervous system. In addition to basic research, she continues a translational research program aimed at bridging findings from the lab to clinical applications. Interactions between the nervous and immune systems are intricate and crucial for normal brain function, with aberrant interactions resulting in severe consequences such as autoimmunity, which can manifest as diverse behavioral and movement disorders. Mentorship and training the next generation of scientists is a priority in her lab, reflecting her own experiences in the importance of guidance and encouragement in scientific research and writing.

Research Interests

Experience

Awards