Dr. Caleigh Mandel Brehm

Biography

Caleigh Mandel-Brehm's research seeks to advance the understanding of the molecular and cellular underpinnings of the basic neuro-immune interactions associated with human autoimmune pathology. Her PhD training was at Harvard Medical School under the guidance of Dr. Michael Greenberg, focusing on molecular neuroscience and behavior. Following that, she broadened her experience as a postdoctoral researcher with Dr. Joseph DeRisi at UCSF, where she built molecular tools to study autoimmune responses in humans with idiopathic neurological disorders. This training places her lab in a unique position to tackle outstanding questions regarding autoimmune pathologies in the central nervous system. Her research goes beyond basic investigations, continuing a translational research program to bridge the findings from bench to bedside. Studying the intricate interactions between the nervous system and the immune system is critical for understanding normal brain function and the severe consequences of aberrant interactions, which can lead to autoimmunity and a range of symptoms, including behavioral and movement disorders. Mentorship and training the next generation of scientists is a priority in her lab, benefiting from a strong mentoring environment.

Research Interests

Awards