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Calvin Roskelley's laboratory focuses on understanding genetic factors regulating tissue architecture, specifically in the context of breast and ovarian carcinoma progression. He has developed specialized three-dimensional models that allow for the recapitulation of normal epithelial tissue architecture in vitro. By modulating the expression and function of cell adhesion molecules in these cultures, his group studies the architectural disruptions that allow epithelial cells to dissociate from the primary tumor and begin invading surrounding tissues. The Roskelley group is particularly interested in identifying specific molecules that regulate the migratory switch in breast and ovarian tumor cells.
Offers course-only and thesis routes. Focus areas include philosophy of science, mind, ethics, and Asian philosophy.