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Calvin Roskelley’s laboratory focuses on understanding genes and genetic products involved in regulating tissue architecture and the progression of breast and ovarian carcinoma. He has developed specialized, three-dimensional models that allow for the recapitulation of normal epithelial tissue architecture in a culture dish. By modulating the expression and function of cell adhesion molecules in these cultures, his research aims to determine how architectural disruption enables epithelial cells to break away from original tumors and begin invading surrounding tissues. The Roskelley group is actively investigating specific molecules involved in the regulatory mechanisms that control the migratory switch in breast and ovarian tumor cells.
Offers course-only and thesis routes. Focus areas include philosophy of science, mind, ethics, and Asian philosophy.