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Caner Saygin, MD, is an Assistant Professor in the Biological Sciences Division at the University of Chicago. His research focuses on acute leukemia, cancer genomics, and clonal hematopoiesis. Dr. Saygin's laboratory investigates the biology of leukemia using in vitro and in vivo models, particularly focusing on acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL). One of the key areas of emphasis in his lab is understanding the mechanisms of clonal hematopoiesis of indeterminate potential (CHIP) and its progression in myeloid and lymphoid leukemias, especially in contexts involving de novo and therapy-related cases. His translational research aims to identify the molecular and cellular mechanisms driving these fatal diseases and to translate these insights into novel therapeutic strategies. His lab's drug development projects particularly address high-risk subsets of AML, which have led to investigator-initiated phase I/II clinical trials based on discoveries made in the lab. Dr. Saygin has published extensively on the topic and continues to explore the impact of various genetic mutations and therapies on leukemia treatment outcomes.
Department of Philosophy